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In the event of an added leap second, a 0-bit is inserted during second 59, and the special missing bit is transmitted during the leap second itself, second There is still a year ambiguity, as the Gregorian calendar repeats weeks every years, but this is sufficient to determine which years ending in 00 are leap years. The phase modulation generally encodes the same data as the amplitude modulation, but differs for bits 59 through 14, inclusive. Bit 59 no amplitude modulation is phase-modulated as a 0-bit. Bits 0—9 are phase modulated as 1 bits, and bits 10—14 are phase modulated as 0 bits. This signal strength assessment was made according to the reflection model with a reflection one hop on the ionospheric D-layer.

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DCF77 is a German longwave time signal and standard-frequency radio station. It started service as a standard-frequency station on 1 January In June date and time information was added. Its primary and backup transmitter are located at in Mainflingen, about 25 km south-east of Frankfurt am Main, GermanyThe transmitter generates a nominal power of 50 kW, of which about 30 to 35 kW.

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But also spare a thought for the historians, for the genesis of this little car is by no means straightforward. But he fell out with Daimler, and was made redundant from his next job at Steyr, which is when he formed his company. He changed his name twice and ending up in America. Ferry applied himself to the needs of the time including agricultural equipment, mowers, tractors, winches and water pumps.

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Burgraviate of Nuremberg and Imperial City of Nuremberg Old fortifications of Nuremberg Nuremberg was, according to the first documentary mention of the city in , the location of an Imperial castle between the East Franks and the Bavarian March of the Nordgau. King Conrad III established a burgraviate , with the first burgraves coming from the Austrian House of Raab but, with the extinction of their male line around , the burgraviate was inherited by the last count’s son-in-law, of the House of Hohenzollern.

From the late 12th century to the Interregnum —73 , however, the power of the burgraves diminished as the Hohenstaufen emperors transferred most non-military powers to a castellan, with the city administration and the municipal courts handed over to an Imperial mayor German: The Diets of Nuremberg were an important part of the administrative structure of the empire.

The increasing demand of the royal court and the increasing importance of the city attracted increased trade and commerce to Nuremberg. In , the Jews of the town were falsely accused of having desecrated the host , and of them were killed in one of the many Rintfleisch massacres. Behind the massacre of was also the desire to combine the northern and southern parts of the city, which were divided by the Pegnitz.

The Jews of the German lands suffered many massacres during the plague years.

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Toyota Crown Majesta for Hongqi models Sedan pre-facelift Avant pre-facelift Interior The third generation Audi , launched in September , had an aerodynamic look, achieving a drag coefficient of 0. The increased aerodynamic efficiency resulted in better fuel economy. The design was in contrast from the boxy shape of the C2.

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Cruz 1 1ECBio S. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Immunogenicity and immunosuppression were assessed by mixed lymphocyte reactions, suppression of lymphocyte proliferation and induction of regulatory T cells. Further, UCX did not need prior activation or priming to exert their immunomodulatory effects.

This was further corroborated in vivo in a model of acute inflammation. The latter were confirmed at the protein expression level. Introduction Mesenchymal stromal cells MSCs from a variety of sources have been described as having interesting immunomodulatory characteristics and have thus been studied in the context of immunotherapy. Lack of expression of MHC II molecules and low expression of MHC I molecules, as well as low level expression of costimulatory molecules such as CD80 and CD86 [ 1 ], all contribute to the low immunogenicity observed in these cells and render them easily accepted in an allogeneic noncompatible donor setting.

Further, MSCs have demonstrated to have other properties that enable their use in allogeneic transplantation and in immunotherapy [ 2 ]. MSCs have also been shown to inhibit B cell proliferation and differentiation [ 4 , 5 ], the proliferation of natural killer NK cells, and their cytokine production [ 6 , 7 ] and to inhibit the ability of dendritic cells to stimulate alloresponses [ 8 — 10 ]. In addition, MSCs are thought to affect peripheral tolerance by inducing Tregs [ 11 , 12 ].

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